The following article is observational study which compared the outcome of dialysis between patients with gout or hyperuricemia who already had CKD stage 5 according the the use of allopurinol or febuxostat. It showed that the hazard ratio for progression to dialysis was less in the febuxostat users than in the allopurinol users.

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Hsu, Yun-Shiuan, I-Wen Wu , Shang-Hung Chang, Cheng-Chia Lee , Chung-Ying Tsai, Chan-Yu Lin, Wan-Ting Lin , Yu-Tung Huang , Chao-Yi Wu, George Kuo , Chih-Yen Hsiao, Hsing-Lin Lin, Chih-Chao Yang, Tzung-Hai Yen, Yung-Chang Chen, Cheng-Chieh Hung, Ya-Chong Tian, Chang-Fu Kuo, Chih-Wei Yang, Gerard F. Anderson and Huang-Yu Yang. “Comparative Renoprotective Effect of Febuxostat and Allopurinol in Predialysis Stage 5 Chronic Kidney Disease Patients: A Nationwide Database Analysis." Clinical Pharmacology and Therapeutics 107, no. 5 (2020): 1159-1169. doi: https://doi.org/10.1002/cpt.1697

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